dearJulius.com Write For Us

HIV genome helps determine antibodies formed in people with the virus

SHARE:

This digitally colorized scanning electron microscopic image reveals green, spherical HIV-1, which had been co-cultivated with human lymphocytes. Researchers have found that HIV plays a major role in determining which antibodies are formed to act against the virus

By Allen Cone, UPI

Researchers found that HIV itself plays a major role in determining which antibodies are formed in people, which may be important for developing a vaccine against it.

A Swiss research team led by the University of Zurich and University Hospital Zurich has been searching for the factors that play a role in these antibodies' production. Their findings were published Monday in the journal Nature.

HIV, which stands for human immunodeficiency virus, spreads through certain body fluids that attack the body's immune system, including T cells. Over time, these infections take advantage of a weak immune system and become acquired immunodeficiency syndrome, or AIDS.

Previously identified factors that played a role in the body's immune response were: the virus load and the diversity of the viruses, the duration of the infection and the ethnicity of the affected person.

"In our new study, we were able to identify another factor: The genome of the HI virus," Dr. Huldrych G√ľnthard, deputy director of the Department of Infectious Diseases and Hospital Epidemiology at University Hospital Zurich, said in a press release.

They studied data and biobanked blood samples from around 4,500 HIV-infected people from the Swiss HIV Cohort Study and the Zurich Primary HIV Infection Study.

Analyzing 53 measured parameters of HIV-1-binding and neutralizing antibody responses, they found 303 potential transmission pairs of patients with similar genomic RNA, meaning they were probably infected with the same virus strain.

"By comparing the immune response of these pairs of patients, we were able to show that the HI virus itself has an influence on the extent and specificity of the antibody reactions," said Dr. Roger Kouyos, research group leader at the Department of Infectious Diseases and Hospital Epidemiology at University Hospital Zurich.

When antibodies act against HIV, they bind to proteins on the surface of the virus. The antibodies also differ based on virus strain and subtype.

The researchers studied patient pairs with similar virus genomes but had strong activity of broadly neutralizing antibodies.

"We discovered that there must be a special envelope protein that causes an efficient defense," said Dr. Alexandra Trkola, virologist and head of the Institute of Medical Virology at the Zurich hospital.

The envelope proteins and virus strains that lead to the formation of broadly acting antibodies must be identified to develop an effective vaccine against HIV-1.

"We have found one candidate. Based on that, we now want to begin developing an immunogen ourselves," Trkola said.

COMMENTS



Note: If you think this story need more information or correction, feel free to comment below your opinion and reaction.
Like & Follow to Stay Updated ...

Name

Body & Mind,3,Fitness,20,Health,1450,Weight Loss,3,Wellness,2,
ltr
item
Health - U.S. Daily News: HIV genome helps determine antibodies formed in people with the virus
HIV genome helps determine antibodies formed in people with the virus
https://3.bp.blogspot.com/-ryBGTRSB7JI/W5jEKh7TeVI/AAAAAAAA9_I/MhQFldhep7A8uffVljjKlynqzczlEbr3wCLcBGAs/s1600/7.jpg
https://3.bp.blogspot.com/-ryBGTRSB7JI/W5jEKh7TeVI/AAAAAAAA9_I/MhQFldhep7A8uffVljjKlynqzczlEbr3wCLcBGAs/s72-c/7.jpg
Health - U.S. Daily News
https://health.dailynews.us.com/2018/09/hiv-genome-helps-determine-antibodies.html
https://health.dailynews.us.com/
https://health.dailynews.us.com/
https://health.dailynews.us.com/2018/09/hiv-genome-helps-determine-antibodies.html
true
6734990777582388991
UTF-8
Loaded All Posts Not found any posts VIEW ALL Read More Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share. STEP 2: Click the link you shared to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy